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[7] The researchers also posit that the lipolytic actions of both hGH and AOD 9604 are not mediated directly through the 3-AR although both compounds increase 3-AR expression, which may subsequently contribute to enhanced lipolytic sensitivity. Growth hormone likely promotes a greater release of fats from adipose cells due to its proposed impact on insulin resistance

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Concurrently, 4-OI reduces the levels of proinflammatory cytokines including TNF- and IL-1 in peripheral blood mononuclear cells and suppresses NF-B activity [63]